• Infiltration anesthesia in the guinea-pig in comparison with bupivacaine >
• Surface anesthesia in the guinea-pig in comparison with bupivacaine.
• Inhibition of sciatic nerve activity (rat) in comparison with bupivacaine.(see also)
• Effects on the sodium channels in cloned human myocites. 
• Hemodynamic and electrophysiological effects of intravenous racemic IQB, L-IQB and bupivacaine in anesthetized dogs.

• Acute i.v. toxicity in rats (in comparison with bupivacaine)
• Effects on action potentials in isolated cardiac fibers in comparison to bupivacaine
• Effects of the enantiomers on cloned human cardiac potassium channels (Kv 1.5)
• Acute i.v. toxicity in mice (Lorcke method)

PHARMACOLOGY

1. Comparative antinoceptive and motor effects of IQB-9302 and bupivacaine given epidurally to dog.
2. Effects on neuronal Na+ channels (comparison with bupivacaine)
3. Effect of IQB-9302 on voltage-dependent Ca2+ channels and neuronal nicotinic receptor ion channels
4. Effect of IQB-9302 on a3b4 neuronal nicotinic receptors expressed in oocytes
5. Comparison of vascular and hemodynamic effects

• Acute s.c. toxicity in mice in comparison with mepivacaine and bupivacaine.
• Subacute intravenous toxicity in rats (Dose-range finding) 
• Subcutaneous acute toxicity in beagle dogs.
• Subacute intravenous toxicity in rats
• Subacute intravenous toxicity in beagle dogs 
• Compatibility with blood and haemolytic potential
• Ames test 
• Full mutagenicity panel

• TOLERANCE AND  LOCAL ANESTHETIC EFFECTS OF INCREASING INTRADERMAL  DOSES OF IQB-9302.HCl 
• DOUBLE-BLIND COMPARISON OF INCREASING INTRADERMAL DOSES IQB-9302 AND BUPIVACAINE GIVEN TO HEALTHY VOLUNTEERS
• DOUBLE BLIND COMPARISON OF IQB-9302 AND BUPIVACAINE  IN THE  BLOCK OF CUBITAL NERVE IN HEALTHY VOLUNTEERS
• Tolerance study and pharmacokinetics after increasing intravenous doses in 16 healthy volunteers