ATLAS DE NEUROLOGIA

ENFERMEDAD DE KRABBE

Patients with the infantile form of Krabbe disease present with irritability and muscle hypertonicity, progressive neurological deterioration, evidence of white matter disease on neuroimaging, signs of peripheral neuropathy, and elevation of cerebrospinal fluid protein concentration. While most patients have the infantile form, older patients ranging in age from six months to the fifth decade have also been diagnosed. They usually present with weakness and vision loss and may experience intellectual regression.