GALENIC FORMULATIONS  OF (±) IQB-9302 HYDROCLHORIDE 

A) FORMULATIONS FOR USE IN ANIMAL STUDIES 
  
The following dose solutions were prepared using purified water, and the osmolality was measured using a calibrated osmometer. 
 
 

 IQB-9302.HCl Solution Osmolality
1 mg/ml (0.0101 g/10 ml)  
2 mg/ml (0.0201 g/10 ml)  
3 mg/ml (0.0301 g/10 ml) 		 3 mOsm 
11 mOsm 
16 mOsm
  
Purified Water   =    0 mOsm 

Physiological Saline (0.9% NaCl) = 279 mOsm 

The following dose solutions were prepared using physiological saline (0.9% Sodium Chloride) and osmolality was again measured using a calibrated osmometer. 
 
 

iQB-9302.HCl  Solution Osmolality
1 mg/ml (0.0101 g/10 ml) 
2 mg/ml (0.0201 g/10 ml) 
3 mg/ml (0.0301 g/10 ml)		 285 mOsm 
290 mOsm 
297 mOsm
  
Normal serum osmolality is between 285 and 310 mOsm.  Reference:  Clinical Diagnosis and Management, 17th edition, Page #122. 

Test article was weighed on a calibrated, electronic, top-loading balance accurate to within ± 0.1 mg.  An additional 0.1 mg was added to each solution to be assured that the solution contained at least the amount indicated. 

On the basis of these data, doses for acute and subacute studies in animals were prepared in normal physiological saline 
 
 PROJECT HOMEPAGE