REFERENCES

 
Liu, PL., Feldman, HS., Giasi, R., Patterson, MK., Covino BG. Comparative CNS toxicity of lidocaine, etidocaine, bupivacaine and tetracaine in awake dogs following rapid i.v. 
administration. Anesth.Analg. (1983): 62: 375-379 

B.G. Covino: Toxicity and Systemic Effects of Local Anesthetic Agents. En Local Anesthetics. Editor:  G.R. Strichartz, Springer-Verlag, (1987) pag.186-212 

H.S.Feldman: Toxicity of Local Anesthetic Agents. En: Anesthetic toxicity. Editado por Susan A.Rice y Kevin J.Fish. Raven Press, (1994)  pag. 107-133 

G.T. Tucker: Pharmacokinetics of Local Anaesthetics. Br.J. Anaesth., (1986), 58 : 717-731 

Local Anaesthetic (Infiltration anaesthesia) action in the guinea-pig.  RCC Project 688173 (1998) 

Local Anaesthetic (superficial anaesthesia) action in the guinea-pig.  RCC Project 688184 (1998) 

Anesthetic activity. Blocking of the sciatic nerve in the anesthetized rat. Report Nº CD98/1 169FD (1998) 

Effects of IQB-9302 on basal and evoked contractions of isolated rat aorta. Report 99/1 (1999) 

R. Ramón. Action of IQB-9302 and its enantiomers on the cellular electrophysiological parameters of the rat ventricle. Comparison with bupivacaine (1998) 

Acute intravenous toxicity test. Determination of DL50 in  rats. Report Nº CD 98/6114T 
(1998) 

Four weeks intravenous dose-range finding  study in the rat. Report Nº CD/6288T (1999) 

IQB-9302: An Acute Subcutaneous Toxicity Study in Beagle Dogs. TPS Report 616B (1999) 

IQB-9302: An Acute Intravenous Toxicity Study in Beagle Dogs. TPS Report 616A (1999) 

Four Week toxicity study in rats by intravenous administration with a two week recovery period. Report CD-98/6289T (1999) 

IQB-9302: A 28 Days Intravenous  Subacute Toxicity Study in Beagle Dogs. TPS Report 616C (1999) 

Compatibility and Haemolytic potential of IQB-9302. Report CD-98/6209T (1999) 

IQB-9302:  Bacterial Mutation Assay. LIS 001/992164 (1999) 

Mª Jose Verde y A.Galiano. Patente Española  Nº 9.302.303 (4 Nov 1993) 
Mª Jose Verde y A. Galiano: US Patent nº 5.834.490 (10 Nov 1998) 

DMF Applicants Part (1999).  

Merck Index XIII. Bupivacaine.  pag. 1520 

URL: http://www.iqb.es/cpcaina/ (Base de Datos en INTERNET con actualizaciones diarias) Es necesario solicitar una clave al Director del Proyecto para acceder a la misma.