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Definición: gastritis que muestra endoscópicamente la presencia de erosiones y hemorragias, debidas a una gran variedad de causas (*). Muchos autores la denominan gastritis hemorrágica. La gastritis crónica implica un cierto grado de atrofia con pérdida de la capacidad funcional de la mucosa) o metaplasia. Afecto sobre todo al antro con pérdida de células G y una disminución de la secreción de gastrina, o al antro, con pérdida de glándulas oxínticas con la consiguiente reducción de la secreción de ácido, de pepsina y de factor intrínseco |
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This condition is defined by the presence of multiple punctate or aphthous ulcers on endoscopy. Chronic erosive gastritis may be idiopathic or caused by drugs (especially aspirin and other NSAIDs--see Treatment under Peptic Ulcer Disease, below), Crohn's disease (see Ch. 31), or viral infections. Helicobacter pylori does not appear to have a major role in the pathogenesis of this condition. Symptoms are nonspecific and may include nausea, vomiting, and epigastric discomfort, although patients are often symptom-free. Endoscopy reveals punctate erosions most frequently on the ridges of thickened rugal folds, often with a central white plaque or umbilication. Histologically, the degree of inflammation varies. No therapy is universally beneficial or curative. Treatment is largely symptomatic with use of antacids, H2 blockers, and proton pump inhibitors (see Treatment under Peptic Ulcer Disease, below) as well as avoidance of potentially exacerbating drugs and foods. Remissions and exacerbations are common. |
