Dexbrompheniramine; Pseudoephedrine Dexaphen S.A®, Disobrom®, Disophrol®, Disophrol Chronotabs®, Drixoral® | Dexaphen S. A.® | Dexophed™ | Drexophed™ SR | Drixomed™ | Drixophed™ | Pharmadrin™e [ Comments ] [ Indications ] [ Product Information ] [ Chemical Structures] Classification: • Adrenergic agonists • Antihistamines • Autonomic Agents • H1-blockers • Sedating H1-blockers • Sympathomimetics Indications: •allergic rhinitis •common cold •nasal congestion Comments: Description: Dexbrompheniramine and pseudoephedrine are used together in an oral preparation to treat upper respiratory congestion and allergic rhinitis. Dexbrompheniramine is an H1-blocker that dries the nasal and sinus passages secondary to its anticholinergic activity. Pseudoephedrine is a sympathomimetic agent that stimulates alpha1-adrenergic receptors in vascular smooth muscle. This causes vasoconstriction, resulting in shrinkage of nasal mucous membranes, reduction of tissue hyperemia and edema, and an increase in nasal airway patency. Available as: Prescription only: Dexaphen S.A.® (Major), Disobrom® (Geneva), per extended-release tablet: dexbrompheniramine maleate 6 mg pseudoephedrine sulfate 120 mg Over-the-counter: Disophrol® (Schering-Plough), per regular-release tablet: dexbrompheniramine maleate 2 mg pseudoephedrine sulfate 60 mg Disophrol Chronotabs® (Schering-Plough), Drixoral® (Schering-Plough), per extended-release tablet: dexbrompheniramine maleate 6 mg pseudoephedrine sulfate 120 mg Dosage: Dexaphen S.A.®, Disobrom®, Disophrol Chronotabs®, Drixoral®, extended-release tablets: Adults: 1 tablet PO every 12 hours. Disophrol® regular-release tablets: